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Some clinical studies have shown an increased risk of heart disease and death in patients with hypothyroidism. Further, an association has been suggested betweenTSHlevelsnear the upper limit of the normal range and death in some studies. This study evaluates the risk of death associated withlevelsofTSHin the normal range. An elevation or drop in the thyroid-stimulating hormone (TSH)levelindicates that the thyroid gland is not functioning properly. TheTSHhormone controls thelevelof T3 and T4 hormones in the body, which in turn carry out various cell functions. Learn aboutTSHlevels, symptoms, causes, treatment, and in newborns. Apr 26, 2025 ·Generally,highTSHis associated with an underactive thyroid and lowTSHmeans an overactive thyroid. Learn how the causes ofTSH levelscan guide treatment. Feb 11, 2025 ·High TSH levels indicatehypothyroidism,which can cause fatigue, weight gain, depression and other symptoms. Learn how to diagnose and treat high TSH levels with thyroid hormone replacement medication and other therapies.