Guy definition: a man or boy; fellow.. See examples of GUY used in a sentence. Learn the meanings and usage of the word guy as a noun, verb, and abbreviation. Find out the origin, synonyms, and related terms of guy in different contexts and dictionaries. Definition of guy noun in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. The verb guy “to ridicule” is derived from this story also. The use of the word was extended to similar figures and then to a person of strange appearance or dress.