Isosorbide dinitrate is an antianginal agent belonging to Nitrate. Isosorbide Dinitrate is used in the prevention and treatment of angina in coronary artery disease. Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with ... Drug information on isosorbide dinitrate (Isordil Titradose , Dilatrate-SR, Isochron), a nitrate prescribed for angina, heart pain, and congestive heart failure. Click for information about side effects, drug interactions, dosage, storage, and pregnancy safety information. Isosorbide Dinitrate belongs to a group of medicines called organic nitrates. Isosorbide Dinitrate is used to prevent and treat angina pectoris and as an adjunctive treatment in severe acute or chronic congestive cardiac failure. Isosorbide dinitrate belongs to the group of medicines called nitrates . It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its work load. When used regularly on a long-term basis, this helps prevent angina attacks from occurring.