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When to Worry about Creatinine Levels Low or High? Discover the factors to consider and when to seek medical advice regarding abnormal creatinine levels . Learn when creatinine levels become concerning, what causes elevated levels , and how to protect your kidney health through proper monitoring and lifestyle changes. Creatinine is a waste product in your blood that comes from normal muscle wear and tear. High creatinine levels can mean kidney damage or dehydration, while low creatinine levels can indicate low muscle mass or malnutrition.