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The USMLE assesses an examinee’s ability to apply knowledge, concepts, and principles, and to demonstrate fundamental patient-centered skills. To apply for USMLE examinations, you must submit an application through the appropriate registration entity as described below. Note: Step 1, Step 2 CK, and Step 3 are not offered on major local holidays. The United States Medical Licensing Examination ( USMLE ) is required to gain a license to practice medicine within the US. It assesses the essential skills for safe and effective patient care and provides a common standard of assessment for medical licensure. This USMLE complete guide will provide all the information you need for applying and undertaking the USMLE , including eligibility, registration and fees, and the different USMLE steps and materials to prepare. USMLE is a three-step examination program for medical licensure in the United States sponsored by FSMB and NBME. It assesses medical knowledge, skills, and understanding of clinical science for U.S. and international medical school graduates.