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Urea is formed, enters the bloodstream, is filtered by the kidneys, and is eventually excreted in the urine. The biochemical part of excretion is urea synthesis using the urea cycle , also known as the Ornithine Cycle. It is also known as the Kreb-Henseleit cycle and occurs in the liver. The urea cycle is the body’s way of converting toxic ammonia into urea. Ammonia originates from protein catabolism whether that is secondary to a high-protein diet, deaminations, or during the period of prolonged starvation. The urea cycle is a type of metabolism in the liver that that changes toxic ammonia into less toxic urea for healthy removal, which is necessary for the body’s nitrogen balance. The urea cycle , also known as the ornithine cycle, is a vital metabolic pathway responsible for the conversion of ammonia into urea. This cycle plays a pivotal role in the body’s mechanism to eliminate excess nitrogen.
