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Phlebitis is inflammation of a vein, while thrombophlebitis is a blood clot causing inflammation. Learn about the types, causes, risk factors, diagnosis, treatment, and prevention of phlebitis and thrombophlebitis . Thrombophlebitis involves the formation of a blood clot in the presence of venous inflammation or injury. Many innate conditions may predispose patients to thrombophlebitis by means of a variety of hypercoagulopathy syndromes. Superficial thrombophlebitis is defined as the inflammation of a superficial vein, typically accompanied by the formation of a blood clot (thrombus) within that vein. This condition often occurs in the legs but can affect veins in other areas of the body. Thrombophlebitis is inflammation of a vein, usually in the leg. It can cause swelling or redness and can lead to a pulmonary embolism if not treated.