NHS medicines information on sulfasalazine – what it's used for, side effects, dosage and who can take it. Sulfasalazine , a potent disease-modifying antirheumatic drug (DMARD), helps manage autoimmune conditions like rheumatoid arthritis and inflammatory bowel disease. This activity discusses sulfasalazine 's therapeutic indications, contraindications, and mechanism of action, crucial elements indispensab … Description Sulfasalazine is used to treat and prevent acute attacks of mild to moderate ulcerative colitis. It works inside the bowels by helping to reduce the inflammation and other symptoms of the disease. Sulfasalazine enteric-coated tablets are used to treat adults and children with rheumatoid arthritis in patients who have not been helped by or who cannot tolerate other medicines (eg, salicylates or NSAIDs) for rheumatoid arthritis. This medicine is available only with your doctor's ... Sulfasalazine is a DMARD used to treat various autoimmune diseases and diabetes. Learn about its working, common side effects, available medicines and expert advice on 1mg.com.