STFU is an informal acronym that stands for Shut The Fuck Up, commonly used to express a strong desire for someone to stop talking or to dismiss their remarks. It is often encountered in online communication and casual conversations. What does STFU mean? The acronym STFU stands for shut the fuck up. It’s often used when people are angry or upset with someone, usually online. STFU is an acronym that can stand for various phrases, such as Shut the Freak Up or Stop Trolling for Unicorns. Find out the full meanings and examples of STFU and other acronyms on this web page. According to Urban Dictionary, STFU stands for shut the f"ck up. This chat slang term is a very rude way of telling someone to be quiet. This term is often used in a joking way with someone one is close with to tell them to knock it off, or to stop talking about a certain topic.