The meaning of STERILIZATION is the act or process of sterilizing. How to use sterilization in a sentence. Definition of sterilization noun in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. Master sterilization in biology-learn key methods, types, and real uses. Boost your exam prep with Vedantu’s expert guide. STERILIZE definition: 1. to perform a medical operation on someone in order to make them unable to have children: 2. to…. Learn more.