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Progesterone is used in the treatment of Hormone replacement therapy, Female infertility. View Progesterone ’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg.com. Progest 100mg Injection contains progesterone , which is a natural female sex hormone. It is used to treat menstrual and pregnancy-related issues that are caused due to hormonal imbalance. It is also prescribed along with estrogen as a part of hormonal replacement therapy for preventing endometrial hyperplasia (thickening of the lining of the uterus). Progesterone injection is a hormone used to treat uterine bleeding, irregular periods, and other conditions. It may cause serious side effects such as blood clots, liver problems, and allergic reactions. Learn more about its dosage, interactions, and precautions. Learn about progesterone injections, a hormone therapy that some doctors prescribe for women with recurrent miscarriages or preterm birth. Find out the benefits, risks, and alternatives of this treatment.