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Pigmentation definition : coloration, especially of the skin.. See examples of PIGMENTATION used in a sentence. What is Pigmentation on face? Pigmentation implies the bodily pigment that gives color to skin. It often results in skin discoloration. Pigmentation is the coloration of tissues by pigment or the deposition of pigment by cells. Learn more about the biological and medical aspects of pigmentation , synonyms, antonyms, and translations.