Pemphigus: Is a group of

Pemphigus is a group of acantholytic conditions caused by autoantibodies against various epidermal cell junction proteins, commonly presenting with flaccid blisters, erosions or scaling Pemphigus is an uncommon autoimmune blistering disease, mediated by antibodies directed against desmosomal adhesion proteins (most particularly desmogleins 1 and 3) that are responsible for maintaining integrity of the epidermis. This article will discuss its epidemiology, pathogenesis, clinical variants and approaches to treatment. What is Pemphigus Vulgaris? Pemphigus Vulgaris is an autoimmune disease that primarily affects the skin and mucous membranes. In this condition, the body's immune system mistakenly attacks proteins in the skin called desmogleins, which are essential for holding skin cells together. This leads to the formation of blisters and erosions, causing significant discomfort and increasing the risk of infections. Pemphigus encompasses a group of potentially life-threatening autoimmune bullous diseases characterised by blisters and erosions of the mucous membranes and skin. Pemphigus vulgaris (PV) is the most common variant and affects skin and mucosa. Pemphigus foliaceus (PF) is confined to the skin. Para...