OMNIPOTENCE definition: 1. unlimited power and the ability to do anything: 2. unlimited power and the ability to do…. Learn more. If you want to describe someone who can do absolutely anything, reach for the adjective omnipotent. Define omnipotence. omnipotence synonyms, omnipotence pronunciation, omnipotence translation, English dictionary definition of omnipotence. adj. Having unlimited or universal power, authority, or force; all-powerful. Someone or something that is omnipotent has complete power over things or people.