Obsession definition : the domination of one's thoughts or feelings by a persistent idea, image, desire, etc.. See examples of OBSESSION used in a sentence. Learn the meaning of obsession , a noun that describes something or someone that you think about all the time. See how to use obsession in sentences and compare it with related words. Learn the meaning of obsession as a noun in British and American English, with synonyms, pronunciation, and usage examples. Find out how obsession relates to psychology, grammar, and other languages. The response to an obsession is often an effort to ignore or suppress the thought or impulse or to neutralize it by a compulsion. See obsessive-compulsive disorder. —obsessional adj. —obsessive adj.