Definition of nope exclamation in Oxford Advanced Learner's Dictionary. Meaning , pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. An Academic Look at NOPE When used to mean "no," NOPE is a slang word. Slang refers to words, phrases and uses of language that are regarded as very informal and which are often restricted to a special context or a particular group of users. When used to mean "Not of Planet Earth," NOPE is an acronym (i.e., an abbreviation spoken like a word). Acronyms differ from initialism abbreviations, which are pronounced using their individual letters. What Did We Say before Texting and Social Media ... Nope definition : no.. See examples of NOPE used in a sentence. Nope is an informal word for no, used as a negative response. Learn its origin, usage, synonyms, and examples from Collins and other sources.