Point of Care - Clinical decision support for Neostigmine. Treatment and management. Indications, Mechanism of Action, Administration, Adverse Effects, Contraindications, Monitoring, Toxicity, Enhancing Healthcare Team Outcomes The drug information on NEOSTIGMINE include structure, IUPAC, physiochemical properties, synthesis, SAR, MOA, therapeutic uses, side effects and MCQs for GPAT and other exam preparations. Neostigmine is a reversible cholinesterase inhibitor. It increases the level of acetylcholine, a chemical messenger in the brain, by suppressing acetylcholinesterase (enzyme). This acetylcholine further triggers muscle contracting receptors which helps in muscle contraction. Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
