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Lysosomes are spherical, membrane bound organelles that are generated by the golgi apparatus. They contain hydrolytic enzymes, and so function as part of the recycling system of the cell.In this article, we will look at the structure, synthesis and function of lysosomes, and we will consider their relevance to clinical practice. Lysosomes Definition Lysosomes definition: Lysosomes are membrane-bound cell organelles containing digestive enzymes that break down macromolecules, cellular debris, and foreign invaders within eukaryotic cells. Structure and Diagram of Lysosomes A typical lysosome is a spherical sac surrounded by a single membrane. The existence of lysosomes was subtly suggested for the first time in the early 1950s by a series of experiments carried out by Nobel Prize Laureate Christian de Duve and his co-workers. These experiments were designed to identify the cellular locus of the two enzymes glucose-6-phosphatase and acid phosphatase. Liver tissue homogenates were separated into nuclear, mitochondrial, microsomal, and cytosol fractions by differential centrifugation and enzyme assays were performed on each ... In addition to breaking down polymers, lysosomes are capable of killing and digesting microbes, cells, or cellular debris. Through cooperation with phagosomes, lysosomes conduct autophagy, clearing out damaged structures and forming simple compounds, which are then used as new building materials.