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Lube definition: substance used to reduce friction between surfaces. Check meanings, examples, usage tips, pronunciation, domains, related words. Discover expressions like " lube job", "lube up", "auto- lube ". To lubricate (a car's joints, for example). n. A lubricant , such as one applied to machinery: silicone lube . [Shortening and alteration of lubricant and lubricate .] American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Lube definition: lubricant.. See examples of LUBE used in a sentence. /lub/ IPA guide Other forms: lubed ; lubing; lubes Definitions of lube noun a substance capable of reducing friction by making surfaces smooth or slippery synonyms: lubricant, lubricating substance, lubricator