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Human metapneumovirus (HMPV) is a virus that causes acute respiratory infection, mostly in children, the elderly, and people with weak immunity. Its symptoms resemble a common cold but can cause respiratory infections like pneumonia and bronchiolitis. Human metapneumovirus (hMPV) is a respiratory virus that causes severe infections in infants, children, and the elderly. We examine the virus’s structure and replication and highlight prophylaxis and treatment for hMPV infections. Human metapneumovirus (hMPV) is a respiratory virus, first reported the year 2001. Since then, it has been described as one of the main etiological agents that causes acute lower respiratory tract infections (ALRTIs), which is characterized by symptoms such as bronchiolitis, wheezing and coughing. | A diagrammatic illustration of the Human Metapneumovirus (hMPV) life cycle, showcasing the various stages of viral replication.