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Definition of efficacy noun in Oxford Advanced Learner's Dictionary. Meaning , pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. Efficacy is the quality of being successful in producing an intended result or effect. Learn how to use this word in different contexts, synonyms, and related terms with Collins English Dictionary. efficacy definition : ability to produce a desired result. Check meanings, examples, usage tips, pronunciation, domains, and related words. Discover expressions like "self- efficacy ", "luminous efficacy ", "prove the efficacy ". Efficacy definition : the capacity for producing a desired result or effect.. See examples of EFFICACY used in a sentence.