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Anti-CCP Antibody (Anti-CCP) — Accurate information on arthritis and its medications This test looks for CCP (cyclic citrullinated peptide) antibodies in your blood. CCP antibodies can be a sign of rheumatoid arthritis. Learn more. The anti-CCP test helps detect anti-CCP antibodies, which are proteins produced by the immune system that mistakenly target the body’s own tissues, particularly proteins modified by citrullination. What is an anti-CCP test used for? The anti-CCP (anti-cyclic citrullinated peptide) test is valuable in the early detection of rheumatoid arthritis (RA) even before clinical symptoms appear. Identifying RA at this stage is crucial for early intervention and preventing extensive joint damage. This test aids in both diagnosing the disease and assessing its severity, helping healthcare professionals provide timely and appropriate care.