Adapalene is a third-generation retinoid that is used to treat mild-moderate acne and keratosis pilaris. It is stable, effective, and well-tolerated, and can be combined with other medications or used as maintenance therapy. Adapalene is a topical medicine similar to vitamin A that helps the skin renew itself and treat severe acne. Learn how to use it, what side effects to watch out for, and what precautions to take before using it. Adapalene is a retinoid-like compound used to treat acne in adults and children 12 years and older. Learn how to apply it, what precautions to follow, and what side effects to watch out for. Adapalene is a topical retinoid with FDA approval for treating acne vulgaris. Retinoids are vitamin A derivatives that are typically described in terms of generations with increased specificity of retinoic acid receptor (RAR) affinity with later generations. Clinicians use retinoids are used to treat a wide variety of skin disorders. Adapalene also has multiple off-label therapeutic applications, including the treatment of verrucae, molluscum contagiosum, Darier disease, Fox-Fordyce disease ...