Acute kidney injury (AKI), previously called acute renal failure (ARF), denotes a sudden and often reversible reduction in kidney function, as measured by glomerular filtration rate (GFR).[1][2][3] However, immediately after a renal insult, blood urea nitrogen (BUN) or creatinine (Cr) levels may be within the normal range, and the only sign of AKI may be a decline in urine output. AKI can lead to the accumulation of water, sodium, and other metabolic products. AKI can also result in other ... During acute kidney failure , kidneys lose their filtering ability and body fluids can rise to dangerous levels. Learn what causes this condition and how to treat it. Acute renal failure is caused by damage to the kidneys, which can occur as a result of blood loss, toxins, or physical damage to the kidneys. Acute renal failure occurs rapidly, causing generalized symptoms, such as nausea and confusion. 1 It is a serious condition, but it can be treated. Acute kidney injury (AKI) is a clinical syndrome manifested by a rapid or abrupt decline in kidney function and subsequent dysregulation of the body electrolytes and volume, and abnormal retention of nitrogenous waste. AKI was formerly known as acute renal failure . AKI is a complex condition with a wide range of causes, including ischemic injury and exposure to nephrotoxic agents. [1] The widely accepted Kidney Disease : Improving Global Outcome (KDIGO) definition of AKI is based on the ...