Define vacation. vacation synonyms, vacation pronunciation, vacation translation, English dictionary definition of vacation. n. 1. A period of time devoted to pleasure, rest, or relaxation, especially one with pay granted to an employee. 2. a. A holiday. b. A fixed period of... The meaning of VACATION is a period spent away from home or business in travel or recreation. How to use vacation in a sentence. Discover the meaning of vacation, what vacation means, and how to use vacation correctly. Complete guide with definitions, examples, and usage tips. Learn about the origin, meaning and usage of the term vacation in different regions and contexts. Explore the benefits and challenges of vacations for health, well-being, creativity and relationships.