Tolperisone is a drug used to treat increased muscle tone caused by neurological diseases or spastic paralysis. It has been in use since the 1960s, but its safety and efficacy are questioned by the European Medicines Agency. Tolperisone is a muscle relaxant for spasticity. Learn about its composition, interactions, warnings, and more on Practo. Tolperisone is a centrally acting muscle relaxant that treats spasticity and muscle spasm. Learn about its indications, contraindications, precautions, interactions, and FAQs from MedicinesFAQ. Tolperisone , a piperidine derivative, is assigned to the group of centrally acting muscle relaxants and has been in clinical use now for decades. The review summarizes the known pharmacokinetics, pharmacodynamics, toxicology and side effects in humans and the clinical use of tolperisone .