How Valcubit Tablet works Valcubit 49mg/51mg Tablet is a combination of two medicines: sacubitril and valsartan, which belong to a class of angiotensin receptor neprilysin inhibitors (ARNI). This combination treats heart failure by relaxing the blood vessels and making it easier for your heart to pump blood throughout your body. Sacubitril + Valsartan is a combination of two medicines: Sacubitril and Valsartan which belong to a class of angiotensin receptor neprilysin inhibitor (ARNI). This combination treats heart failure by relaxing the blood vessels and making it easier for your heart to pump blood throughout your body. Sacubitril and Valsartan tablets are a combination medicine widely prescribed for the treatment of chronic heart failure. The formulation helps reduce the strain on the heart and improves overall cardiac function. How Sacuvart Tablet works Sacuvart 24mg/26mg Tablet is a combination of two medicines: sacubitril and valsartan, which belong to a class of angiotensin receptor neprilysin inhibitors (ARNI). This combination treats heart failure by relaxing the blood vessels and making it easier for your heart to pump blood throughout your body.