Prochlorperazine is a medication used to treat nausea, migraines, schizophrenia, psychosis and anxiety. It is a less preferred medication for anxiety and has common side effects such as sedation and extrapyramidal symptoms. Prochlorperazine is a medicine that helps stop you feeling or being sick, such as in pregnancy sickness, motion sickness or Ménière's disease. Learn how to take it, possible side effects, pregnancy and breastfeeding advice, and interactions with other medicines. Prochlorperazine is a phenothiazine drug used to treat anxiety, nausea, vomiting, and schizophrenia. It can cause serious side effects such as low blood pressure, low white blood cell count, liver problems, and tardive dyskinesia. Prochlorperazine is a phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting.