Perseverance definition : steady persistence in a course of action, a purpose, a state, etc., especially in spite of difficulties, obstacles, or discouragement.. See examples of PERSEVERANCE used in a sentence. "Perseverance" Definition: What Does "Perseverance" Mean? "Perseverance" refers to unwavering determination and consistent effort in the pursuit of a goal, even in the face of difficulties or setbacks. The meaning of PERSEVERANCE is continued effort to do or achieve something despite difficulties, failure, or opposition : the action or condition or an instance of persevering : steadfastness. How to use perseverance in a sentence. Definition of perseverance noun in Oxford Advanced Learner's Dictionary. Meaning , pronunciation, picture, example sentences, grammar, usage notes, synonyms and more.