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Penile cancer affects the penis . Explore penile cancer symptoms, causes, diagnosis methods, and treatment options including surgery, radiation, and chemo. Penile cancer often starts on the skin cells of your penis and can work its way inside. Learn more about the causes, risk factors, symptoms, diagnosis, treatments, and prevention of penile cancer . Penile cancer is a rare but serious disease that affects the tissues of the penis . It is important to have an understanding of this condition in order to raise awareness and promote early detection and treatment. Penile cancer , or penile carcinoma, is a cancer that develops in the skin or tissues of the penis . Symptoms may include abnormal growth, an ulcer or sore on the skin of the penis , and bleeding or foul-smelling discharge.