While many maculopapular rashes are mild and self-limiting, some can be severe and potentially fatal. 2 This article reviews the causes, symptoms, diagnosis, and treatment of maculopapular rashes, with a focus on the 2 most common etiologies: drug-induced and viral-induced. Maculopapular rash Maculopapular rashes, characterized by erythematous macules and papules that can coalesce into plaques and patches, are the most common cutaneous IRAE. The lesions tend to appear on the trunk and extremities (often in photo-exposed areas) sparing the palms and soles, and associated pruritis is common [64,69,70,72]. Histology reveals eczema-like spongiotic dermatitis with a superficial perivascular T-lymphocytic infiltrate with predominant CD4 +, predominant CD8 +, or mixed ... Maculopapular rash is a non-specific term for an acute and generalised skin eruption of flat and raised lesions. Learn about the common and uncommon causes, how to diagnose and manage them, and see images and videos of different types of maculopapular rash. A maculopapular rash is a symptom of infection, allergy, or medication reaction. It causes flat and raised lesions on the skin that may itch or spread. Learn how to identify, diagnose, and treat this type of rash.