It's possible to have a higher than usual lymphocyte count but have few, if any, symptoms. The higher count usually comes after an illness. It is most often harmless and doesn't last long. But the higher count might be the result of something more serious, such as a blood cancer or a chronic infection. Having too many lymphocytes ( lymphocytosis ) may be a sign of an infection, thyroid disease, or certain blood cancers. Having too few lymphocytes (lymphopenia) may be a sign of an autoimmune disease, genetic disorder, or bone marrow failure caused by anemia, chemotherapy, or radiation. In children, until the immune system matures (which happens at age 7 or 8), the lymphocyte range is slightly high . A lymphocyte count that is lower or higher than this range should be evaluated to find out the underlying cause and seek necessary treatment. What does it mean when your lymphocytes are high? High lymphocyte count in human blood refers to a condition called lymphocytosis which is very common in people after getting affected by an infection.