Huntington disease , an autosomal dominant inherited neurodegenerative disorder, is characterized by the clinical triad of involuntary choreiform movements with cognitive and behavioral disturbances. It occurs due to cytosine, adenine, and guanine (CAG) trinucleotide repeats on the short arm of chromosome 4p16.3 in the Huntingtin (HTT) gene. This mutation leads to an abnormally long polyglutamine expansion in the HTT protein's N-terminal fragment, which leads to neurodegeneration. The ... Huntington disease (HD) is an incurable, adult-onset, autosomal dominant inherited disorder associated with cell loss within a specific subset of neurons in the basal ganglia and cortex. HD is named after George Huntington , the physician who described it as hereditary chorea in 1872. Huntington disease (HD) is a genetic disorder in which nerve cells in certain parts of the brain waste away, or degenerate. The disease is passed down through families. Huntington disease is a rare hereditary neurological disease characterized by irregular and involuntary movements of the muscles and progressive loss of cognitive ability. The disease was first described by American physician George Huntington in 1872.
