Learn about the causes, symptoms, diagnosis and treatment of Hirschsprung 's disease , a congenital condition that affects the large intestine. Find out how surgery can help children with this blockage to pass stools normally. Hirschsprung disease , a neurocristopathy, is the most common cause of neonatal colonic obstruction (15-20%). It is commonly characterized by a short segment of colonic aganglionosis affecting term neonates, especially boys. Rarely, it can present in patients >10 years, termed adult Hirschsprung disease . Hirschsprung Disease , also known as congenital aganglionic megacolon, is a rare but serious condition that affects the large intestine (colon) of infants. It is characterized by the absence of nerve cells in certain parts of the colon, leading to problems with bowel movements Hirschsprung Disease occurs when nerves are missing in parts of the colon, leading to bowel obstruction. Learn about its symptoms, causes and treatment!