Herpes is a condition caused by a virus called the Herpes Simplex Virus (HSV). Explore the types, causes, symptoms and treatment options available. Herpes is caused by the herpes simplex virus. There are two types, oral herpes and genital herpes , which are usually sexually transmitted. Find out more here. HERPES definition : 1. an infectious disease that causes painful red spots to appear on the skin, especially on the…. Learn more. Herpes simplex is an infectious virus spread through skin contact or sexual transmission of HSV-1 or HSV-2, a virus that causes oral herpes or genital herpes , causing itchiness, blistering, cold sore