Coombs test: The pediatric hematologist is

The pediatric hematologist is concerned about autoimmune hemolytic anemia and orders a direct antiglobulin test (DAT), which is negative and requests a peripheral blood smear, which shows increased spherocytes and polychromasia in the image above. Negative direct antiglobulin test (DAT) (i.e., Coombs test ) Elevated cardiac troponins or lactate Schistocytes on peripheral blood film or complete blood count (CBC) differential (see Peripheral smear images) Coombs test / DAT is used to determine whether a patient’s red blood cells (RBCs) are coated with immunoglobulins or complement in vivo Follicular peripheral T cell lymphoma (F-PTCL) is a rare subtype of nodal lymphomas of TFH cell origin with a follicular or perifollicular growth pattern exhibiting strong and consistent expression of T follicular helper (TFH) markers.