assholenoun[C] (BODY PART) the anus (Definition of asshole from the Cambridge Advanced Learner's Dictionary & Thesaurus © Cambridge University Press) Asshole definition: anus.. See examples of ASSHOLE used in a sentence. Define asshole . asshole synonyms, asshole pronunciation, asshole translation, English dictionary definition of asshole . n. Vulgar Slang 1. The anus. 2. A contemptible or detestable person. 3. The most miserable or undesirable place in a particular area. American Heritage®... Asshole is a vulgar (dirty) slang word. Besides the literal meaning, it’s a common word for a jerk or idiot.
