The Anti-CCP test detects the presence of antibodies directed against cyclic citrullinated peptides, which are proteins found in the joints. In rheumatoid arthritis, the immune system mistakenly attacks healthy joint tissues, leading to inflammation, pain, and joint damage. Levels of anti-CCP can be detected in a patient through a simple blood test . A positive anti-CCP test result can be used in conjunction with other blood tests, imaging tests, and/or physical examination findings to diagnose rheumatoid arthritis. The Anti-CCP test is a blood test that detects the presence of antibodies directed against the body’s cyclic citrullinated peptide ( CCP ). These antibodies are frequently detected in the blood of people with rheumatoid arthritis. A CCP test may be necessary if a doctor thinks you have rheumatoid arthritis. Here’s what else is necessary to make a diagnosis and what the results mean.