Learn about Amyloidosis , including symptoms, causes, and treatments. If you or a loved one is affected by this condition, visit NORD to find resources and Amyloidosis is a heterogeneous disease that results from the deposition of toxic insoluble beta-sheet fibrillar protein aggregates in different tissues. Amyloidosis can be acquired or hereditary. The disease can be localized or systemic. Amyloid can accumulate in the liver, spleen, kidney, heart, ne … Amyloidosis is a rare disease that causes abnormal protein deposits in the body's organs. Learn about the different types, signs, tests and therapies for this condition from Johns Hopkins Medicine. Amyloidosis is a group of rare conditions where a protein called amyloid builds up in your body and affects organs such as your heart, kidneys, liver or nerves. Learn about the different types of amyloidosis , how they're diagnosed and treated, and how to cope with the condition.