AGITATION definition : 1. worry and anxiety : 2. the situation in which people protest or argue, especially in public, in…. Learn more. Agitation definition : the act or process of agitating; state of being agitated : agitated .. See examples of AGITATION used in a sentence. Agitation is a state of heightened motor and cognitive activity characterized by excessive or inappropriate verbal and physical behaviors, emotional excitement, and restlessness, often arising as a symptom of underlying medical, psychiatric, or neurological conditions. [1][2][3] It is considered both a medical and psychiatric emergency due to ... Agitation is a state of excitement, disturbance, or worry, or the act of moving something vigorously. Learn more about its meaning , synonyms, and usage in sentences from Collins English Dictionary.